Endocrine Abstracts

We present a 67 years old male originally from Cyprus who presented with Hypercalcemia. He had renal calculi twice and required Laparoscopic procedure. In his family history his 3 siblings had confirmed raised calcium and PTH and 2 other siblings had renal calculi. One of his brother, had surgery for primary hyperparathyroidism twice but no parathyroid adenoma was found and his calcium remained high. Patients’ calcium was 2.81 mmol/l (2.15–2.50), 25 HVD 82 nmol/l (75...

Introduction: Common causes of generalised seizures are epilepsy, meningitis, head injury and hypoglycaemia. But this is an unusual presentation of generalised seizures secondary to hypocalcaemia due to prolonged use of PPI’s. PPI’s are amongst the most commonly prescribed drugs due to their effective medicinal profile. They are generally well tolerated, however, are now increasingly reported to be associated with adverse effects. There has been some discrepancy abou...

The prevalence of adrenal incidentaloma on abdominal Computed Tomography (CT) is around 4.4%. This prevalence is increased in obese, diabetic, hypertensive patients, and could be as high as 10% in older patients. Unilateral adrenal masses larger than 4 cm should be considered for surgical removal to avoid missing adrenal carcinoma, particularly in younger patients.This is the case of a 67 year old gentleman with Type 2 diabetes mellitus, known to have hy...

Current UK guidelines for thyroid nodules advise a thyroid ultrasound (ThyUSS) with U-Classification with or without Fine Needle Aspiration (FNA) with Thy-Classification to determine malignancy risk. We report four cases where thyroid carcinoma was diagnosed histologically following reassuring cytology and radiological examination. This is a case of 28-year-old female who presented with neck swelling. ThyUSS showed an enlarged left thyroid with cystic and solid components; FNA...

Background: Despite the widespread use of the 250-μg Cosyntropin test (ACTH test) for the diagnosis of adrenal insufficiency (AI), the effect of timing of the test on 30- vs. 60-min serum cortisol values remains unclear. Also, there is limited evidence comparing the value of performing both 30- and 60-min cortisol levels.Methods: We conducted a retrospective cohort study of all ACTH tests conducted at the Halifax Neuropituitary Program, Nova Scotia,...

Background: Diabetes mellitus (DM) affects nearly is reported to be present in approximately 8% of cases of elective hip arthroplasty and an HBA1c >53 mmol/mol may be associated with poorer outcomes in these cases.Aims: To understand the demographics of DM patients in Glasgow undergoing elective hip arthroplasty over a 6 year period between Jan 2009 and Dec 2015 and the rate of post-operative complications.Methods: Patients wer...

Background: The hypothalamic–pituitary–adrenal axis has a pivotal role in combating acute insults. Glucocorticoids play a role directly or indirectly in the maintenance of normal vascular tone and in potentiating the vasoconstrictor action of catecholamine, associated with septic shock.Aims: To determine the incidence of adrenal insufficiency (AI) and its relation to mortality in patients with septic shock.Settings and de...

Introduction: Diabetes is associated with dysfunction, and failure of different organs, especially the eyes, kidneys, nerves, heart, and blood vessels. Diabetic macrovascular complications are the leading cause of deaths in diabetics. The correlation between LVH and LVDD with HbA1c is not clear in newly diagnosed T2DM Indian diabetics.Aims and objective: To study the frequency of left ventricular hypertrophy (LVH) and left ventricular diastolic dysfuncti...

Background: Diabetic ketoacidosis is characterised by biochemical tired of hyperglycemia, acidosis, and ketonemia. It remains a life threatening condition despite improvement in diabetic care, timely identification and intervention remains the backbone of treatment.Aim and objectives: i) To evaluate the clinical and biochemical prognostic markers in diabetic ketoacidosis. ii) To correlate the various prognostic markers with mortality in diabetic ketoacid...

Background: The metabolic syndrome is one of the fastest growing epidemics of the modern era in both the industrialised as well as developing world. Waist circumference (WC) is an important component to diagnose metabolic syndrome. Cut off point of WC to diagnose metabolic syndrome is different in.different ethnic groups.Objective: To study and correlate the variation in prevalence of metabolic syndrome depending on the site of waist measurement and to s...